| Spider-Man, Hometown Hero (6 variants) | 857 |
| Spider-Gwen, Free Spirit (8 variants) | 874 |
| Spectator Seating (4 variants) | 495 |
| Spectator Seating (12 variants) | 268 |
| Spectacular Tactics (8 variants) | 775 |
| Spark Double (12 variants) | 279 |
| Spark Double (4 variants) | 337 |
| Spaceshift (8 variants) | 640 |
| Songbird, Sonic Screamer (12 variants) | 762 |
| Solemn Simulacrum (12 variants) | 215 |
| Solemn Simulacrum (4 variants) | 453 |
| Soldier On (6 variants) | 843 |
| Sol Ring (2 variants) | 211 |
| Sol Ring (2 variants) | 213 |
| Sol Ring (2 variants) | 214 |
| Sol Ring (2 variants) | 212 |
| Sodden Verdure (4 variants) | 494 |
| Sodden Verdure (12 variants) | 267 |
| Smoldering Marsh (4 variants) | 493 |
| Smoldering Marsh (12 variants) | 266 |
| Smashing Spree (6 variants) | 856 |
| Smashing Spree (12 variants) | 555 |
| Sky Cycle (8 variants) | 704 |
| Skullclamp (12 variants) | 210 |
| Skullclamp (4 variants) | 451 |
| Silver Surfer, Galactus's Herald (4 variants) | 293 |
| Silver Surfer, Galactus's Herald (12 variants) | 10 |
| Silver Surfer, Cosmic Voyager (8 variants) | 639 |
| Sif's Spearmaster (12 variants) | 765 |
| Shuri's Fabricator (4 variants) | 450 |
| Shuri's Fabricator (12 variants) | 114 |
| Shuri, Vibranium Technologist (8 variants) | 746 |
| Shuri, the Black Panther (12 variants) | 95 |
| Shuri, the Black Panther (4 variants) | 416 |
| Shock (8 variants) | 809 |
| Shipwreck Patrol (8 variants) | 638 |
| Shi'ar Soldier (8 variants) | 637 |
| She-Hulk, Wallbreaker (12 variants) | 60 |
| She-Hulk, Wallbreaker (4 variants) | 372 |
| She-Hulk, Jennifer Walters (12 variants) | 554 |
| She-Hulk, Attorney-at-Law (8 variants) | 745 |
| Shang-Chi, Martial Mentor (8 variants) | 732 |
| Shang-Chi and the Ten Rings (12 variants) | 94 |
| Shang-Chi and the Ten Rings (4 variants) | 415 |
| Selfless Police Captain (8 variants) | 774 |
| Seize the Day (12 variants) | 166 |
| Seize the Day (4 variants) | 371 |
| Secure Detention (8 variants) | 608 |
| Secluded Courtyard (12 variants) | 265 |
| Scout the City (8 variants) | 817 |