| Search Warrant (22 variants) | 193 |
| Security Blockade (22 variants) | 20 |
| Seek the Horizon (22 variants) | 134 |
| Selesnya Charm (22 variants) | 194 |
| Selesnya Guildgate (22 variants) | 246 |
| Selesnya Keyrune (22 variants) | 233 |
| Selesnya Sentry (22 variants) | 21 |
| Seller of Songbirds (22 variants) | 22 |
| Sewer Shambler (22 variants) | 75 |
| Shrieking Affliction (22 variants) | 76 |
| Skull Rend (22 variants) | 195 |
| Skyline Predator (22 variants) | 50 |
| Skymark Roc (22 variants) | 196 |
| Slaughter Games (22 variants) | 197 |
| Slime Molding (22 variants) | 135 |
| Slitherhead (22 variants) | 222 |
| Sluiceway Scorpion (22 variants) | 198 |
| Slum Reaper (22 variants) | 77 |
| Soul Tithe (22 variants) | 23 |
| Soulsworn Spirit (22 variants) | 51 |
| Spawn of Rix Maadi (22 variants) | 199 |
| Sphere of Safety (22 variants) | 24 |
| Sphinx of the Chimes (22 variants) | 52 |
| Sphinx's Revelation (22 variants) | 200 |
| Splatter Thug (22 variants) | 105 |
| Stab Wound (22 variants) | 78 |
| Stealer of Secrets (22 variants) | 53 |
| Steam Vents (22 variants) | 247 |
| Stonefare Crocodile (22 variants) | 136 |
| Street Spasm (22 variants) | 106 |
| Street Sweeper (22 variants) | 234 |
| Sundering Growth (22 variants) | 223 |
| Sunspire Griffin (22 variants) | 25 |
| Supreme Verdict (22 variants) | 201 |
| Survey the Wreckage (22 variants) | 107 |
| Swamp (22 variants) | 260 |
| Swamp (22 variants) | 261 |
| Swamp (22 variants) | 263 |
| Swamp (22 variants) | 262 |
| Swamp (22 variants) | 264 |
| Swift Justice (22 variants) | 26 |
| Syncopate (22 variants) | 54 |
| Tablet of the Guilds (22 variants) | 235 |
| Tavern Swindler (22 variants) | 79 |
| Teleportal (22 variants) | 202 |
| Temple Garden (22 variants) | 248 |
| Tenement Crasher (22 variants) | 108 |
| Terrus Wurm (22 variants) | 80 |
| Thoughtflare (22 variants) | 203 |
| Thrill-Kill Assassin (22 variants) | 81 |