| Umbral Mantle | 101 |
| Under-Construction Skyscraper | 620 |
| Underworld Breach (2 variants) | 200 |
| Unholy Heat | 63 |
| Unnatural Selection | 38 |
| Uro, Titan of Nature's Wrath | 93 |
| Urza, Lord High Artificer | 244 |
| Urza's Bauble (2 variants) | 237 |
| Urza's Saga | 114 |
| Value Town // Take a Trip to... | 621 |
| Veil of Summer | 75 |
| Velukan Dragon (2 variants) | 145 |
| Veteran Explorer | 76 |
| Vuzzle Spaceship | 569 |
| Walking Ballista (2 variants) | 238 |
| Wasteland | 115 |
| Werewhat | 587 |
| Whiteout | 77 |
| Who's That Praetor? | 506 |
| Winds of Change (2 variants) | 201 |
| Wisedrafter's Will | 539 |
| Wish | 64 |
| Wishclaw Talisman | 51 |
| Wormhole Warp | 570 |
| Worst Fears | 52 |
| Wowzer, the Aspirational | 604 |
| Wrath of Leknif | 605 |
| Wrenn and One | 588 |
| Xantcha, Sleeper Agent | 253 |
| Yawgmoth's Day Planner | 555 |
| Yorion, Sky Nomad | 94 |
| You Compleat Me | 556 |
| Your Wish Is My Command | 540 |
| Zombie Master (2 variants) | 188 |
| Zone of Flame | 571 |