| Rent Is Due (8 variants) | 247 |
| Rent Is Due (12 variants) | 11 |
| Rhino, Barreling Brute (12 variants) | 140 |
| Rhino's Rampage (12 variants) | 141 |
| Risky Research (12 variants) | 62 |
| Robotics Mastery (12 variants) | 41 |
| Rocket-Powered Goblin Glider (12 variants) | 172 |
| Rocket-Powered Goblin Glider (8 variants) | 281 |
| Romantic Rendezvous (12 variants) | 86 |
| Sandman, Shifting Scoundrel (8 variants) | 266 |
| Sandman, Shifting Scoundrel (12 variants) | 112 |
| Sandman's Quicksand (12 variants) | 63 |
| Savage Mansion (12 variants) | 183 |
| Scarlet Spider, Ben Reilly (12 variants) | 214 |
| Scarlet Spider, Ben Reilly (12 variants) | 142 |
| Scarlet Spider, Kaine (12 variants) | 143 |
| School Daze (12 variants) | 42 |
| Scorpion, Seething Striker (12 variants) | 64 |
| Scorpion's Sting (12 variants) | 65 |
| Scout the City (12 variants) | 113 |
| Secret Identity (12 variants) | 43 |
| Selfless Police Captain (12 variants) | 12 |
| Shadow of the Goblin (8 variants) | 262 |
| Shadow of the Goblin (12 variants) | 87 |
| Shock (12 variants) | 88 |
| Shocker, Unshakable (12 variants) | 89 |
| Shriek, Treblemaker (12 variants) | 144 |
| Silk, Web Weaver (12 variants) | 145 |
| Silk, Web Weaver (12 variants) | 215 |
| Silver Sable, Mercenary Leader (12 variants) | 13 |
| Sinister Hideout (12 variants) | 184 |
| Skyward Spider (12 variants) | 146 |
| SP//dr, Piloted by Peni (12 variants) | 147 |
| SP//dr, Piloted by Peni (12 variants) | 199 |
| Spectacular Spider-Man | 241 |
| Spectacular Spider-Man | 239 |
| Spectacular Spider-Man | 235 |
| Spectacular Spider-Man | 237 |
| Spectacular Spider-Man (12 variants) | 14 |
| Spectacular Spider-Man | 240 |
| Spectacular Spider-Man | 238 |
| Spectacular Spider-Man | 236 |
| Spectacular Tactics (12 variants) | 15 |
| Spider Manifestation (12 variants) | 148 |
| Spider-Bot (12 variants) | 173 |
| Spider-Byte, Web Warden (12 variants) | 44 |
| Spider-Girl, Legacy Hero (12 variants) | 149 |
| Spider-Gwen, Free Spirit (12 variants) | 90 |
| Spider-Ham, Peter Porker (12 variants) | 201 |
| Spider-Ham, Peter Porker (12 variants) | 114 |