| Sigarda's Aid (19 variants) | 384 |
| Silas Renn, Seeker Adept (9 variants) | 536 |
| Silverback Shaman (18 variants) | 255 |
| Simic Charm (19 variants) | 451 |
| Simic Growth Chamber (19 variants) | 492 |
| Simic Guildgate (19 variants) | 493 |
| Simic Signet (19 variants) | 471 |
| Simic Sky Swallower (19 variants) | 452 |
| Siren Stormtamer (18 variants) | 96 |
| Sisay's Ring (18 variants) | 340 |
| Skaab Goliath (18 variants) | 97 |
| Skilled Animator (18 variants) | 98 |
| Sky Diamond (18 variants) | 341 |
| Skyraker Giant (18 variants) | 199 |
| Skywhaler's Shot (18 variants) | 46 |
| Slash the Ranks (18 variants) | 47 |
| Slash the Ranks (8 variants) | 625 |
| Slaughter the Strong (18 variants) | 48 |
| Slayers' Stronghold (19 variants) | 494 |
| Slinn Voda, the Rising Deep (19 variants) | 405 |
| Slith Ascendant (18 variants) | 49 |
| Slurrk, All-Ingesting (18 variants) | 256 |
| Slurrk, All-Ingesting (9 variants) | 584 |
| Sol Ring (8 variants) | 700 |
| Sol Ring (19 variants) | 472 |
| Soul of Eternity (18 variants) | 50 |
| Soul of Eternity (8 variants) | 626 |
| Soul's Fire (18 variants) | 200 |
| Soul's Might (18 variants) | 257 |
| Soulfire Eruption (18 variants) | 201 |
| Soulfire Eruption (8 variants) | 670 |
| Spark Harvest (18 variants) | 150 |
| Sparktongue Dragon (18 variants) | 202 |
| Spectator Seating (8 variants) | 711 |
| Spectator Seating (18 variants) | 356 |
| Spectral Searchlight (18 variants) | 342 |
| Sphinx of the Second Sun (8 variants) | 643 |
| Sphinx of the Second Sun (18 variants) | 99 |
| Sphinx of Uthuun (19 variants) | 406 |
| Spirit Mantle (19 variants) | 385 |
| Spitting Image (19 variants) | 453 |
| Spontaneous Mutation (18 variants) | 100 |
| Sporemound (19 variants) | 437 |
| Squad Captain (18 variants) | 51 |
| Sram, Senior Edificer (19 variants) | 386 |
| Staff of Domination (8 variants) | 701 |
| Staff of Domination (18 variants) | 343 |
| Staunch Throneguard (18 variants) | 344 |
| Stingerfling Spider (18 variants) | 258 |
| Stone Quarry (19 variants) | 495 |