| Spirit | 1341 |
| Spirebluff Canal (2 variants) | 1373 |
| Spinerock Knoll (2 variants) | 439 |
| Sphinx of the Second Sun (2 variants) | 1720 |
| Sphere of Safety (2 variants) | 280 |
| Sphere of Safety | 2331 |
| Sphere of Safety | 588 |
| Sphere of Safety (2 variants) | 2316 |
| Sphere of Resistance | 1484★ |
| Sphere of Resistance | 1484 |
| Spellstutter Sprite | 117 |
| Spellskite (2 variants) | 2325 |
| Spellskite (2 variants) | 587 |
| Spellskite (2 variants) | 277 |
| Spellskite | 2340 |
| Spellseeker (2 variants) | 1165 |
| Spell Queller (2 variants) | 193 |
| Spell Pierce | 41 |
| Spell Pierce (2 variants) | 2388 |
| Species Specialist (2 variants) | 2369 |
| Sower of Temptation (2 variants) | 120 |
| Sovereign Okinec Ahau (2 variants) | 2695 |
| Soulherder (2 variants) | 2174 |
| Soul's Attendant | 7147 |
| Soul-Scar Mage (2 variants) | 2039 |
| Soul-Scar Mage | 2044 |
| Soul-Scar Mage (2 variants) | 190 |
| Soul-Guide Lantern (2 variants) | 871 |
| Soul Warden (2 variants) | 1708 |
| Soul Warden | 2435 |
| Sorin, Vengeful Bloodlord | 524 |
| Sorin, Imperious Bloodlord | 1244 |
| Sorin, Grim Nemesis (2 variants) | 400 |
| Sorin Markov (2 variants) | 1698 |
| Sorcerous Spyglass | 693 |
| Sonic the Hedgehog (2 variants) | 2087 |
| Sonic Screwdriver (2 variants) | 803 |
| Song of the Worldsoul | 2434 |
| Song of the Dryads (2 variants) | 2027 |
| Song of Creation (4 variants) | 1603 |
| Solve the Equation (2 variants) | 886 |
| Solve the Equation (2 variants) | 1022 |
| Solve the Equation | 2570 |
| Solitude | 7004 |
| Solemn Simulacrum (4 variants) | 1113 |
| Solemn Simulacrum | 791★ |
| Solemn Simulacrum (2 variants) | 1725 |
| Solemn Simulacrum | 791 |
| Sol Ring // Sol Ring | 1512 |
| Sol Ring (2 variants) | 1664 |