| Saheeli, Sublime Artificer (2 variants) | 1143 |
| Sakashima of a Thousand Faces // Sakashima of a Thousand Faces (2 variants) | 1541 |
| Sakashima the Impostor (2 variants) | 1232 |
| Sakashima's Student (2 variants) | 2359 |
| Sakashima's Student (2 variants) | 2355 |
| Sakura-Tribe Elder (2 variants) | 192 |
| Sakura-Tribe Elder (2 variants) | 2518 |
| Samut, Tyrant Smasher | 535 |
| Samut, Voice of Dissent (2 variants) | 1451 |
| Sanctum Prelate (2 variants) | 278 |
| Sanguine Bond (2 variants) | 1799 |
| Saproling (2 variants) | 1139 |
| Sarkhan the Masterless | 514 |
| Sarkhan Vol (2 variants) | 1144 |
| Sarkhan, Dragonsoul | 1245 |
| Sarulf, Realm Eater (4 variants) | 2240 |
| Saskia the Unyielding | 55 |
| Satoru Umezawa (2 variants) | 2283 |
| Savor the Moment (2 variants) | 1006 |
| Savra, Queen of the Golgari (2 variants) | 500 |
| Saw in Half (2 variants) | 1755 |
| Scaled Nurturer (2 variants) | 7101 |
| Scattered Groves (2 variants) | 2523 |
| Scavenging Ooze | 135 |
| Scheming Symmetry | 1520★ |
| Scheming Symmetry | 1520 |
| Scheming Symmetry (2 variants) | 1997 |
| Scholar of New Horizons | 7143 |
| Scion of Draco (2 variants) | 2031 |
| Scion of Draco | 7026 |
| Scion of the Ur-Dragon | 1531 |
| Scourge of the Throne (2 variants) | 1033 |
| Scourge of Valkas | 1490★ |
| Scourge of Valkas | 1490 |
| Scrawling Crawler | 2399 |
| Screeching Sliver | 622 |
| Scrying Sheets (4 variants) | 1606 |
| Sculpting Steel | 864 |
| Scute Swarm (2 variants) | 7048 |
| Scuttling Sliver | 623 |
| Search for Azcanta // Azcanta, the Sunken Ruin (2 variants) | 1502 |
| Seasoned Dungeoneer | 7144 |
| Seasoned Dungeoneer (2 variants) | 2505 |
| Seat of the Synod (2 variants) | 301 |
| Secluded Glen (2 variants) | 1323 |
| Second Harvest (2 variants) | 2380 |
| Second Harvest (2 variants) | 1611 |
| Secret Rendezvous (2 variants) | 1892 |
| Secret Rendezvous (2 variants) | 2648 |
| Secrets of the Dead (2 variants) | 7099 |