| Seedguide Ash | LRW-235 |
| Seedborn Muse | C19-179 |
| Sedris, the Traitor King | ALA-193 |
| Sedraxis Specter | MM3-181 |
| Sedgemoor Witch | STX-86 |
| Sedge Sliver | TSP-177 |
| Secrets of the Golden City | RIX-52 |
| Second Sunrise | MRD-20 |
| Secluded Glen | WOC-166 |
| Season of Growth | M20-191 |
| Seaside Citadel | MKC-288 |
| Seaside Citadel | ALA-229 |
| Searslicer Goblin | FDN-93 |
| Searing Spear | M13-147 |
| Searing Light | OGW-33 |
| Searing Blaze | WWK-90 |
| Search the City | RTR-49 |
| Search Party Captain | MID-32 |
| Search for Tomorrow | IMA-185 |
| Search for Glory | KHM-27 |
| Search for Azcanta // Azcanta, the Sunken Ruin | XLN-74 |
| Sealock Monster | DDO-42 |
| Seal of Strength | EMA-184 |
| Seal of Removal | NEM-42 |
| Seal of Fire | NEM-98 |
| Seal of Doom | C15-135 |
| Seal of Cleansing | EMA-26 |
| Seahunter | NEM-41 |
| Sea Scryer | MIR-90 |
| Sea of Clouds | BBD-84 |
| Sea Gate Oracle | C17-92 |
| Sea Gate Oracle | KHC-43 |
| Sea Gate | CLB-359 |
| Scuttling Death | MM2-94 |
| Scuttlemutt | SHM-263 |
| Scurry Oak | MH2-172 |
| Scrying Sheets | CSP-149 |
| Scryb Ranger (2 variants) | TSP-215 |
| Scrounger of Souls | HOU-76 |
| Scroll Thief | DDT-17 |
| Scroll Rack | TMP-308 |
| Scroll of the Masters | FRF-163 |
| Screamreach Brawler | DTK-155 |
| Scrapwork Rager | BRO-123 |
| Scrapwork Mutt | BRO-164 |
| Scragnoth | TMP-253 |
| Scourge of the Throne (2 variants) | CNS-35 |
| Scourge Devil | MM3-111 |
| Scoured Barrens | C18-276 |
| Scoria Cat | PCY-101 |