| Equilibrium | EXO-32 |
| Epicure of Blood | M19-95 |
| Epic Downfall | ELD-85 |
| Epic Confrontation | DTK-185 |
| Ephemerate | MH1-7 |
| Ephemeral Shields | M15-11 |
| Entreat the Dead | C18-15 |
| Entreat the Angels | AVR-20 |
| Entreat the Angels | MM3-4 |
| Enthralling Victor | BBD-176 |
| Ensoul Artifact | M15-54 |
| Enlisted Wurm | ARB-68 |
| Enlightened Tutor | MIR-14 |
| Enlightened Maniac | EMN-58 |
| Enlightened Ascetic | ORI-12 |
| Enlarge | M14-170 |
| Engineered Might | KLD-181 |
| Energy Flux | MMQ-78 |
| Energy Field | USG-73 |
| Enduring Victory | DTK-16 |
| Endrek Sahr, Master Breeder | TSP-106 |
| Endoskeleton | USG-294 |
| Endling | MH1-89 |
| Endless Wurm | USG-249 |
| Endless Scream | TMP-132 |
| Endless Obedience | M15-94 |
| Endless Atlas | C18-55 |
| Enclave Cryptologist | ROE-66 |
| Encircling Fissure | BFZ-23 |
| Enchanted Evening | SHM-140 |
| Enchanted Carriage | ELD-218 |
| Encampment Keeper | XLN-11 |
| Emrakul's Hatcher | DDP-59 |
| Emrakul, the Aeons Torn | ROE-4 |
| Empyrial Armor | WTH-13 |
| Empyrean Eagle | M20-208 |
| Empty-Shrine Kannushi | BOK-2 |
| Empty the Warrens | DDS-15 |
| Empress Galina | INV-54 |
| Empowered Autogenerator | C19-54 |
| Emmessi Tome | EMA-221 |
| Emmara, Soul of the Accord | GRN-168 |
| Emissary of Sunrise | XLN-10 |
| Emeria, the Sky Ruin | ZEN-213 |
| Emeria Shepherd | BFZ-22 |
| Emeria Angel | ZEN-11 |
| Emerge Unscathed | IMA-19 |
| Embodiment of Spring | KTK-39 |
| Embereth Shieldbreaker // Battle Display | ELD-122 |
| Embercleave | ELD-120 |