| Supreme Will | HOU-49 |
| Suq'Ata Firewalker | MIR-94 |
| Sure Strike | GRN-118 |
| Surge of Salvation | MOM-41 |
| Surgical Skullbomb | ONE-243 |
| Surrakar Banisher | DDO-43 |
| Survival Cache | IMA-34 |
| Survive the Night | SOI-41 |
| Survivors' Encampment | HOU-184 |
| Suspicious Bookcase | M19-246 |
| Suture Priest | NPH-25 |
| Svella, Ice Shaper | KHM-230 |
| Swamp | JMP-59 |
| Swamp | MKM-282 |
| Swamp | LCI-398 |
| Swamp | WOE-271 |
| Swamp | HOU-195 |
| Swans of Bryn Argoll | MM2-199 |
| Swarm of Rats | P02-89 |
| Swarming Goblins | AFR-162 |
| Swashbuckling | XLN-167 |
| Sweatworks Brawler | AER-100 |
| Swell of Courage | MOR-26 |
| Swelter | JUD-101 |
| Swift Justice | RTR-26 |
| Swift Kick | KTK-122 |
| Swiftfoot Boots (2 variants) | A25-234 |
| Swiftfoot Boots | M12-219 |
| Swiftfoot Boots | BLC-286 |
| Swiftwater Cliffs | C18-284 |
| Sword of Feast and Famine | 2XM-296 |
| Sword of the Animist | E01-89 |
| Sword of the Animist | ORI-240 |
| Sword of the Chosen | STH-141 |
| Sword of Vengeance (2 variants) | M11-216 |
| Sword of War and Peace | 2XM-300 |
| Swords to Plowshares | C16-78 |
| Swords to Plowshares | VOC-99 |
| Sygg, River Cutthroat | ZNC-103 |
| Sylvan Bounty | E01-74 |
| Sylvan Scrying | BFZ-192 |
| Symbiosis | USG-275 |
| Symbiotic Beast | ONS-287 |
| Symbol of Unsummoning | POR-70 |
| Syncopate | DOM-67 |
| Syndic of Tithes | GTC-26 |
| Syr Alin, the Lion's Claw | ELD-32 |
| Syr Elenora, the Discerning | ELD-67 |
| Syr Konrad, the Grim | ELD-107 |
| Sythis, Harvest's Hand | MH2-214 |